alz;;y;m;r i#s;Iz; (ae.#I.) v; B;;rt;Iy; k:rI p;;v;#r
alz;;y;m;r i#s;Iz; ( ae.#I.) h; m;jj;;s;]sq;ec;; Rh;s; k:r[;;r; r;eg; (Neurodegenerative disease) g;eDy;; k:;hI v;{;;*t; s;v;;*t; B;It;Id;y;k: r;eg; @rl; as;Un; t;;e k|:ns;rcy;; p;]iT;:t; j;;W:n; b;s;l; a;he. 4.5 im;lIy;n; am;eirk:n; l;ek:;]n;; Hy;; re;g;;c;I l;g;[; a;j;v;r z;;lI a;he v; 2050 p;y;]*t; ae.#I. cy;; re;gy;;]c;I s;]Ky;; it;pp;! h;ewl as;; a]d;j; a;he. ae.#I. h; re;g; Wt;;rv;y;;t; h;et;;e v; b;hut;ek: s;v;* b;eb;I b;Um;s;* (Born between 1946-1964) l;Ek:rc; ir!;y;r vh;y;cy;; v;y;;l; y;et; as;Dy;;m;uLe ty;;t;le K;Up;s;e y;; re;g;;c;I ix;k:;r b;n;;y;c;; s;]B;v; a;he.
ae.#I. h; r;eg; k:Q;IhI n; b;r; h;e[;;r; v; s;]q;p;[;e p;s;r[;;r; as;Un; Hy;; r;eg;;t; hLUhLU sm;r[;x;iT;:c;; n;;x; h;et;;e, v;;g;[;Uk:It; iv;ic;F;p;[;; y;et;;e v; r;egy;;c;; m;UL sv;B;;v; v; ty;;c;I iv;c;;r k:r[y;;c;I x;iT;: n;;hIx;I h;et;e. m;Qy;m;v;y;In; v; Wt;;rv;y;;t;Il l;ek:;]cy;; sm;r[;x;iT;:c;; Rh;s; k:r[;;r; h; aek:m;ev; r;eg; a;he. h; re;g; j;evh; b;L;v;t;;e t;evh; re;g;I sv;t;/c;e n;;v;hI a;@v;U x;k:t; n;;hIt; v;; a;rx;;s;m;;er WB;e r;hIle t;rI t;e sv;t;/cy;; p;>it;ib;]b;;l; a;rx;;t; a;eLK;U x;k:t; n;;hIt;.
g;eDy;; k:;hI v;{;;*t; z;;leDy;; x;;sF;Iy; s;]x;;eQ;n;;t; as;] a;$LUn; a;l] a;he k:I h; re;g; m;jj;;p;ex;I]n;; a;|iks;#ei!vh wj;; (Oxidative damage)z;;Dy;;m;uLe v; m;jj;;s;]sq;et; g;;@I in;m;;*[; z;;Dy;;m;uLe h;et;;e. a;l;ews; alz;;y;m;y;r (Alzeimer) Hy;; j;m;*n; x;;sF;N;n;e h; re;g;;c;; p;>q;m; 1906 s;;lI x;;eQ; l;v;l; t;evh; ty;;n;e v;e#s;rp;[;;m;uLe (Dementia)m;r[; p;;v;leDy;; aek:; 51 v;{;;*cy;; m;ihles;]b;]Q;I B;;{;[; k:ele. ty;; b;;w*c;I m;r[;;eT;r t;p;;s;[;I (a;|!;eps;I ) k:eDy;;n;]t;r ty;;l; Hy;; m;ihlecy;; m;jj;;s;]sq;et;Il p;ex;I]b;;her s;UZm; g;;@I a;$LDy;; t;r k:;hI p;ex;I]cy;; a;t; t;]t;Um;y; g;;eLe s;;p;#le. ty;;v;eLI h; re;g; as;;Qy; v;;!Dy;;m;uLe aek:hI f:;m;;*sy;ui!k:l k:]p;n;I Hy;; re;g;;s;;@I r;eg;p;>it;b;]Q;k: a;E{;Q;;c;I in;im;*t;I k:r;y;l; p;u$e a;lI n;;hI. p;[; 1976 s;;lI p;I!r #eivhs; n;;v;;cy;; aek:; ib;>!Ix; m;jj;;x;;sF;N;n;e v; ty;;cy;; c;m;Un;e -j;e a;t;; a;Db;!* a;wn;s!;wn; k:;|lej; a;|f: m;ei#s;In; , ny;Uy;;|k*: m;Q;e a;het;-, as;] d;K;v;Un; idl] k:I “
ae.#I.m;Q;e Acetylecholine a|is;!Ilk:;elIn; - ae.s;I .-Hy;; m;jj;;s;]sq;ecy;; c;ln;v;ln;;s;;@I j;r:r as;[;;Ry;; v; m;e]dUt; in;m;;*[; h;e[;;Ry;; G;!k:;c;I p;;t;LI k:m;I as;t;e. ae.s;I. l; ny;Ur;e!M;ns;m;I!r mh[;t;;t;. Hy;; G;!k:;m;uLe m;e]dUcy;; aek:; p;ex;Ic;; dus;Ry;; p;ex;Ib;r;eb;r s;]b;]Q; i!k:Un; rh;t;;ee. Acetylechline esterase a|is;!Ilk:;elIn; aes!rez; - ae.s;I.w* .-he aenz;;wm; ae.s;I.c;; n;;x; ( i#g;e>#ex;n; ) k:rt;e.
Hy;; x;;eQ;;n;]t;r ik:ty;ek: f:;m;*sy;ui!k:l k:]p;ny;;n;I he ae.s;I.w.aenz;;wm; hec; lZy; (Target)@rv;Un; ty;;c;I v;;$ q;;]b;v;[;;Ry;; a;E{;Q;;cy;I in;im;*t;I k:r;y;l; s;ur:v;;t; k:elI. a;j;im;t;Il; s;h; t;e s;;t; a;E{;Q;e b;;j;;r;t; Wp;lbQ; a;het; p;[; dude*v;;n;e ty;;t;le aek:hI a;E{;Q; ae. #I. h; re;g; r;eK;U x;k:t; n;;hI v;; b;r; k:r: x;k:t; n;;hI. aev;$]c; n;;hI t;r y;; a;E{;Q;;]c;e du{p;ir[;;m; wt;k:e G;;t;k: a;het; k:I K;Up;s;e x;;sF;N y;; a;E{;Q;;]cy;; Wp;y;ukt;t;eiv;{;y;Ic; x;]k:; Gy;;y;l; l;g;le a;het;.
p;[; g;eDy;; k:;hI v;{;;*t; f:;m;;*sy;ui!k:l k:]p;ny;;]s;;@I aek: in;r;Lec; lZy; Wp;lbQ; z;;lele a;he. t;e mh[;j;e aee.#I. p;ex;]!cy;; m;e]dUt; j;m;leDy;; g;;@I. hI g;;@ mh[;j;e dus;r]it;s;r] k:;hI n;s;Un; ae.#I. p;ex;]!cy;; m;e]dUt; s;;@[;;Ry;; b;e!; aim;l;y;#;ej;ein;k: p;ep!;w# (Beta amilidogenic peptide) y;; p;>iq;n;;c;; k:;hI a]x; a;he. in;re;g;I m;;[;s;;cy;; m;e]dUt; he b;e!; aim;l;\w# p;ep!;w# (Beta amiloid peptide) k:;hI aenz;;wms;cy;; m;dt;In;e b;e!; aim;l;y;#;ej;ein;k: ip;>k:s;*r p;>;e!In; -(Beta amilidogenic precursor protein) ik:]v;; ae.p;I.p;I. y;; m;;e@y;; p;>iq;n;;cy;; s;;K;LIv;j;; p;&q;kk:r[;;t;Un; in;m;;*[; z;;lele as;t;e. p;[; ae.#I.z;;leDy;; r;egy;;cy;; ae.p;I.p;I .m;Q;e b;dl h;et;;t; ik:]v;; ty;;cy;; p;&q;kk:r[;;t;Un; aek: in;r;Lec; v; G;;t;k: b;e!; a|im;l;|w# p;ep!;w# he p;>iq;n; b;;her p;#t;e v; ty;;m;uLe m;]edUt; g;;@I h;e[y;;s; s;urv;;t; h;et;e . Hy;; g;;@I]m;uLe m;e]dUt; s;]dex; de[;;Ry;; y;]F;[;et; ib;G;;# h;et;;e v; ae.#I. z;;leDy;; p;ex;]!cy;; sm;r[;x;iT;:t; b;dl vh;v;y;;s; l;g;t;;e. Hy;; g;;@I in;m;;*[; k:r[;;Ry;; aenz;;wms;c;; n;;x; k:r[;;rI a;E{;Q;e x;;eQ;Un; k:;$[;;Ry;; an;ek: k:]p;ny;; g;eDy;; dh; aek: v;{;;*t; am;ierk:;, k:|n;#; v; y;ur;ep;m;Q;e in;G;;leDy;; a;het;. k:;hI k:;hI b;;y;;e!ek: k:]p;ny;;]n;I ae.#I. iv;r:à re;g;p;>it;b;]Q;k: ls; ( vh|iks;In; ) b;n;v;;y;l; s;ur:v;;t; k:elI a;he. Hy;; ls;Im;uLe b;e!; a|im;l;|w# p;ep!;w# iv;r:à a|!Ib;;|#I (Antibody) t;y;;r h;eW:n; g;;@I b;n;[y;;c;I iF;:y;; q;;]b;t;e.
ae.#I. Hy;; re;g;;m;Qy;e b;e!; a|im;l;|w# p;ep!;w# h; G;!k: j;m;[;e, p;ex;In;; a;|iks;#ei!vh wj;; h;e[;e v; m;e]dUcy;; p;ex;In;; s;Uj; y;e[;e hI p;>iF;:y;; as;Dy;;m;uLe k:;hIk:;hI x;;sF;N;]n;I ae.#I.cy;; r;egy;;]s;;@I s!|i!ns; ( k:;eles!er;|l k:m;I k:r[;;rI a;E{;Q;] ) v;; a;y;b;UUp;>;ef:en; a;i[; ny;;p;>;ekz;en; ( s;Uj; k:m;I k:r[;;rI a;E{;Q;]) y;;]c;;hI v;;p;r k:el; a;he p;[; ty;;c;; f:;rs;; Wp;y;;eg; z;;lel; n;;hI.
j;;g;it;k: s;]x;;eQ;n;;t; aek: n;v;l;c;I g;;e{! ax;I a;$LUn; a;lI k:I ae.#I .c;] p;>m;;[; B;;rt;Iy; l;ek:;]m;Qy;e am;eirk:n; l;ek:;]cy;; 4.4 !kke: a;he. ty;; s;]x;;eQ;k:;]n;; K;Up; t;p;;s;;a]t;I as;] ids;Un; a;l] k:I B;;rt;Iy; l;ek: j;I k:rI p;;v;#r K;;t;;t; ty;;m;uLec; he p;>m;;[; k:m;I a;he. k:rI p;;v;#rm;Q;Il G;!k:;]c;e j;evh; p;&q;kk:r[; k:el t;evh; s;]x;;eQ;k:;]n;; ty;;t; k:urk:uim;n; (Curcumin)h; G;!k: p;>;m;uKy;;n;e s;;p;#l;, j;;e hLdIm;Q;e K;Up; p;>m;;[;;t; a;$Lt;;e. B;;rt;Iy; a;y;uv;e*d;t; v; G;rg;ut;I a;E{;Q;;t; g;elI ik:ty;ek: x;t;ke: hLdIc;; a|}i!se;p!Ik: mh[;Un; Wp;y;;eg; k:el; j;;t; a;he. l;|s; a|j;e]ils;m;Q;e as;leDy;; y;uin;vhis;*!I a;|f: k:|ilf:;ein;*y;;t;Il #;|. k:e;l v; ty;;]cy;; s;;q;Id;r;]n;I ae.#I. v;r Wp;;y; mh[;Un; hLdIv;r s;|x;;eQ;n; k:r;y;l; s;ur:v;;t; k:elI v; ty;;m;Q;Un; s;;p;#lele an;ek: a;Sc;y;*k:;rk: p;#t;;Le ty;;]n;I j;n;*l a;|f: b;;y;;|l;ij;k: k:eim;s!MI Hy;; Ky;;t;n;;m; m;;is;k:;cy;; f:eb;u>v;;rI 2005 cy;; a]k:;t; %;p;le . t;e K;;lIlp;>m;;[;e a;het;.
k:uk:*uim;n; k:;|]g;;e re# (Congo Red)Hy;; p;d;Q;;*s;;rK;;c; a;he. k:;|g;e; re#c;; Wp;y;;eg; a|im;l;|w# b;e!; p;ep!;w#l; @Lk: (Staining) k:r[y;;s;;@I v;;p;rt;;t;. p;r]t;u m;htv;;c;; f:rk: mh[;j;e k:uk*u:im;n; k:;|g;;e re# s;;rK;; iv;{;;rI n;;hI ix;v;;y; ty;;cy;; iv;ix;{! m;;]#[;Im;uLe k:uk:u*im;n;c;; bl# b;>en; b;|rIy;r m;Q;Un; ix;rk:;v; h;eW:n; ty;;c;; m;e]dUm;Q;Il a|im;l;|w#b;r;eb;r s;]y;;eg; h;eW: x;k:t;;e. wt;r K;Up;x;; a;E{;Q;;t; n; a;$L[;;rI hI iv;ix;{! v; m;htv;;c;I b;;b; f:T;: k:uk:*im;n; Hy;; p;d;q;;*t;c; s;;p;#t;e.
Hy;; s;]x;;eQ;k:;n;I ae.#I. c;e j;n;uk: (gene) k:;hI W]dr;]cy;;t; G;;lUn; p;>y;;eg; k:r;y;l; s;ur:v;;t; k:elI. he W]dIr j;evh; mh;t;;re z;;le t;evh; ty;;]cy;; b;dlleDy;; j;n;uk:;]m;uLe ty;;]cy;; m;e]dUt; a|im;l;|w# s;;@Un; ty;;]n;; ae.#I .h; re;g; z;;l;. ty;; W]dr;]m;Qe; j;evh; k:uk:*im;n; v;;p;rle t;evh; he a|im;l;|w# s;;@[;e n;us;t;e b;]d z;;le n;;hI p;[; ty;;c;e j;m;lele s;;@ehI n;{! z;;le. b;e!; a|im;l;|w# p;ep!;w#c;e s;;@e k:m;Ie k:r[y;;t; ku:ku:*im;n;, a;y;b;up;>ef:en; ny;;p;>;ekz;en; Hy;; a;E{;Q;;p;eZ;;hI j;;st; s;rs; h;et;e.
!es! !y;Ubs;m;Q;e k:eleDy;; s;]x;;eQ;n;;t;hI k:uku:*im;n;m;uLe b;e!; a|im;l;|w# p;ep!;ew#c;e j;m;lele s;;@e n;;hIs;e z;;le v; s;;@v;[; h;e[y;;c;I Z;m;t;; k:m;I z;;lI. Hy;; s;]x;;eQ;n;;c;; wt;k:; f:;y;d; a;$LDy;;m;uLe #;|. k:;el v; ty;;]cy;; s;hk:;Ry;;]n;I a;t;; k:uk:*uim;n;c;e p;>y;;eg; ae.#I.re;g; z;;leDy;; p;ex;]!v;r s;ur: k:ele a;het;. p;ex;I]n;; h;e[;;rI a;|iks;#e!Ivh wj;; v; s;Uj; k:m;I k:r[y;;c;I t;;k:d k:uk:*im;n; Hy;; p;d;q;;*m;Q;ee as;Dy;;m;uLe k:|ns;r v;; #;y;b;ei!s; y;; re;g;;]m;Qy;ehI k:uk:*uim;n;c;; Wp;y;;eg; h;eW: x;k:t;;e. k:;hI k:;eiry;n; s;]x;;eQ;k:;]n;; a;t;#y;;cy;; k:|ns;rcy;; r;egy;;]v;r k:eleDy;; p;>;q;im;k: c;;c;[;Im;Q;ehI k:uk:*im;n;c;e a;x;;j;n;k: p;ir[;;m; p;;h;y;l; im;L;le a;het;.
p;[; k:uk:*uim;n;c;e wt;k:e iv;Q;;y;k: Wp;y;;eg; as;Un;hI f:;m;;*sy;ui!k:l k:]p;ny;; ae.#I. s;;@I k:uk:*im;n;m;Q;Un; a;E{;Q;;c;I in;im;*t;I k:r[y;;s;;@I n;;K;U{; a;het;. as;] k:; ? k:;r[; k:uk:*im;n; v;r p;e!]! im;LU x;k:t; n;;hI. k:u@Dy;;hI s;;Qy;;x;; k:eim;k:l k:]p;n;It; k:uk:u*im;n; h; p;d;q;* iv;k:t; G;et;; y;eW: x;k:t;;e. B;;rt; y;; aek:m;ev; dex;;l; hLdIc;e p;e!]! a;he, jy;;t; k:uk:*im;n; h; G;!k: a;$Lt;;e .hDlIc; aek:; b;;y;;e!ek: k:p;n;In;e k:uk:u*im;n;s;;rK;Ic; r;s;;y;in;k: m;;]#[;I ( ke:im;k:l k:;|mp;;eiz;x;n; ) as;[;;r; p;d;q;* x;;eQ;Un; k:;$l; a;he. p;[; ty;;c;I Wp;y;uT;:t;; K;Up;c; k:m;I a;he v; t;;e bl#b;>en; b;\iry;rm;Q;e ix;rk:;v; k:r: x;k:t; n;;hI, j;I k:uk:*uim;n;c;I K;;s; K;ub;I a;he. ix;v;;y; ty;;t; as;leDy;; k:;hI G;!k:;]cy;; iv;{;;rI p;ir[;;m;;]m;uLe t;e a;E{;Q; k:s;Dy;;hI s;]x;;eQ;n;;tm;k: c;;c;[;It; WT;I[;* h;eW: x;k:t; n;;hI.
Hy;;m;Q;Un; aek: m;htv;;c;; v; lZ;;t; G;e[y;;s;;rK;; m;uä; mh[;j;e wt;k:e s;;ep;sk:;r k:r:n; k:uku:*im;n;c;I wt;k:I m;h;g; g;;eLI x;;eQ;Un; k:;$[y;;c;I k:!k:! k:r;y;c;I k:;hI j;r:r a;he k:; ? Hy;;v;rc;; s;;ep;; a;I[; sv;st; p;y;;*y; mh[;j;e j;ev;[;;t; n;us;t;I k:rI p;;v;#r v;;p;r;y;c;I . n;;hI k:; ?
1. p;>iq;n; mh[;j;e s;;K;LI as;lelI a\im;n;;e a|is;#s;<
2. aenz;;wms; hI deK;Il p;>iq;n;ec; as;t;;t; p;[; ty;;t; k:|!|il!Ik: r;s;;y;in;k: p;>iF;:y;; k:r[y;;c;I t;;k:d as;t;e.
leK;k: - #;|. y;x;v;]t; k:;rK;;n;Is;
an;uv;;d - #;|. m;In;; n;eork:r
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